人类及动物体骨组织不断地进行着重建,骨重建过程包括骨的分解吸收与新骨的形成。破骨细胞(Osteoclast,OC)负责骨分解与吸收,而成骨细胞(osteoblast,OB)负责新骨形成。破骨细胞贴附在旧骨区域,分泌酸性物质溶解矿物质,分泌蛋白酶消化骨基质,形成骨吸收陷窝;其后,成骨细胞移行至被吸收部位,分泌骨基质,骨基质矿化而形成新骨。破骨与成骨过程的平衡是维持正常骨量的关键。
欧宝体育官方 科学技术作为专业的生命科学领域解决方案供应商,为您推荐39年老品牌,Kamiya畅销欧宝体育官方 ,众多Nature文章使用认证!
欧宝体育官方 名称 | 货号 | 实验方案 | 说明书下载 |
TRAP Staining Kit抗酒石酸酸性磷酸酶TRAP 染色试剂盒 | KT-008 | ① 96孔板上染色细胞。② 细胞培养上清TRAP活性测定 |
破骨细胞TRAP染色 | 破骨细胞培养上清液中TRAP活性的测定 |
TRAP Staining Kit,Nature文章结果鉴赏:
①【Nature Medicine, IF=87.2】
TRAP stain: TRAP染色 (osteoclasts (o/c))
② 【Nature Biomedical Engineering, IF=29.2】A multi-organ chip with matured tissue niches linked by vascular flow
TRAP stain: TRAP染色
TRAP Activity: TRAP活性
【更多发表文章】
Sherlock, Jonathan P et al. "IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells". Nature medicinevol.18,7 (2012): 1069-76.
Ronaldson-Bouchard, Kacey et al. "A multi-organ chip with matured tissue niches linked by vascular flow". Nature biomedical engineering vol🐻.6,4 (2022): 351-371. doꦇi:10.1038/s41551-022-00882-6
Bae, Sung-Jin et al. "Ninjurin1 positively regulates osteoclast development by enhancing the survival of prefusion osteoclasts". Experimental & molecular medicine vol.51,1 (2019): 1-16.
Kang, J., Choi, Y.J., Seo, B.Y. et al. A Selective FGFR inhibitor AZD4547 suppresses RANKL/M-CSF/OPG-dependent ostoclastogenesis and breast cancer growth in the metastatic bone microenvironment. Sci Rep 9, 8726 (2019).
Zhang, Lan, et al. "Adiponectin ameliorates experimental periodontitis in diet-induced obesity mice."PloS one 9.5 (2014): e97824.
Kang, Moo Rim et al. "Agelasine D suppresses RANKL-induced osteoclastogenesis via down-regulation of c-Fos, NFATc1 and NF-κB". Marine drugs vol.12,11 (2014): 5643-56.
Sherlock, Jonathan P., et al. "IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+ CD4? CD8? entheseal resident T cells."Nature medicine18.7 (2012): 1069-1076.
Kim, Jinkoo, et al. "Erythropoietin mediated bone formation is regulated by mTOR signaling."Journal of cellular biochemistry113.(2012): 220-228.
Lee, Yu-Chen, et al. "Src family kinase/abl inhibitor dasatinib suppresses proliferation and enhances differentiation of osteoblasts."Oncogene 29.22 (2010): 3196-3207.
Lu, Yi et al. "Activation of MCP-1/CCR2 axis promotes prostate cancer growth in bone". Clinical & experimental metastasis ♔vol.26,2 (2009): 161-9. doi:10.1🎃007/s10585-008-9226-7
Geng, Weidong et al. "Inhibition of osteoclast formation and function by bicarbonate: role of soluble adenylyl cyclase". Journal of cellular physiology vol.220,2 (2009): 332-40.
Simonaro, Calogera M., et al. "Mechanism of glycosaminoglycan-mediated bone and joint disease: implications for the mucopolysaccharidoses and other connective tissue diseases."The American journal of pathology172.1(2008): 112-122.
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